Lsd

Table of Contents Introduction Table 1:Effects of LSD A Brief Foray Into Philosophy and the Cognitive Sciences The Suspects Figure 1: Structure of LSD Overview of Synaptic Transmission Theory: LSD Pre-synaptically Inhibits 5-HT Neurons Theory: LSD Post-synaptically Antagonizes 5-HT2 Receptors Figure 2: LSD Binding at 5-HT2 Receptor Theory: LSD Post-synaptically Partially Agonizes 5-HT2 Receptors Theory: LSD Post-synaptically Agonizes 5-HT1 Receptors Conclusion References Introduction The psychedelic effects of d-Lysergic Acid Diethylamide-25 (LSD) were discovered by Dr. Albert Hoffman by accident in 1938. In the 1950s and 1960s, LSD was used by psychiatrists for analytic psychotherapy. It was thought that the administration of LSD could aid the patient in releasing repressed material. It was also suggested that psychiatrists themselves might develop more insight into the pathology of a diseased mind through self experimentation. 1,2 During the late 60s, LSD became popular as a recreational drug. While it has been suggested that recreational use of the drug has dropped, a recent report on CNN claimed that 4.4% of 8th graders have tried it. LSD is considered to be one of, if not the, most potent hallucinogenic drug known. Small doses of LSD (1/2 - 2 ug/kg body weight) result in a number of system wide effects that could be classified into somatic, psychological, cognitive, and perceptual categories. These effects can last between 5 and 14 hours. Table 1: Effects of LSD 1, 2, 3 Somatic Psychological Cognitive Perceptual mydriasis hallucinations disturbed thought processes increased stimulus from environment hyperglycemia depersonalization difficulty expressing thoughts changes in shape/color hyperthermia reliving of repressed memories impairment of reasoning synaesthesia (running together of sensory modalities) piloerection mood swings (related to set and setting) impairment of memory - esp. integration of short -> long term disturbed perception of time vomiting euphoria lachrymation megalomania hypotension schizophrenic-like state respiratory effects are stimulated at low doses and depressed at higher doses reduced "defenses", subject to "power of suggestion" brachycardia The study of hallucinogens such as LSD is fundamental to the neurosciences. Science thrives on mystery and contradiction; indeed without these it stagnates. The pronounced effects that hallucinogens have throughout the nervous system have served as potent demonstrations of difficult to explain behavior. The attempts to unravel the mechanisms of hallucinogens are closely tied to basic research in the physiology of neuroreceptors, neurotransmitters, neural structures, and their relation to behavior. This paper will first examine the relationship between neural activity and behavior. It will then discuss some of the neural populations and neurotransmitters that are believed to by effected by LSD. The paper will conclude with a more detailed discussion of possible ways that LSD can effect the neurotransmitter receptors which are probably ultimately responsible for its LSD. A Brief Foray Into Philosophy and the Cognitive Sciences Modern physics is divided by two descriptions of the universe: the theory of relativity and quantum mechanics. Many physicists have faith that at some point a "Grand Unified Theory" will be developed which will provide a unified description of the universe from subatomic particles to the movement of the planets. Like in physics, the cognitive sciences can describe the brain at different levels of abstraction. For example, neurobiologists