Shikimic Acid Fermentation

In the Name of God

Biotechnology MSc. Seminar:

Current issues in production of Shikimic Acid, intermediate for the production of Oseltamivir, the Avian Flu drug

Supervised by:

Dr. Reza Yegani

Dr. Mohammad Hossein Sarrafzadeh

Mr. Habibollah Ramezanzade

by:

Kaveh Yazdifard

Presented on:

1385/10/3

Contents

Acknowledgement

Introduction

Shikimic Acid & its Natural Properties

Derivatives of Shikimic Acid

Avian Flu Sickness, Medications

Oseltamivir and Shikimic Acid's Role in Synthesis

Production of Shikimic Acid

Extracting Shikimic Acid from the Plant

Chemical Synthesis of Shikimic Acid

Biosynthesis & Shikimic Acid Pathway

Fermentation of Shikimic Acid using Microorganisms

Contrasting Production Methods & Advantages of Fermentative method

Investigating Appropriate Strains

Results & Future Aspects of Shikimic Acid Fermentation

References

Acknowledgement

The achieved results in this seminar and the upcoming relevant project are owing to undeniable helps and support of Zakaria Pharmaceutical Co.’s CEO Mr. Ramezanzadeh & my colleagues in R&D sector, mainly the R&D director Dr. Jassouri.

In clarifying my viewpoints on the project and on making a better literature work for the present seminar I strongly benefited from the helps of Dr. Sarrafzadeh and Dr. Yegani, to whom I shall always be grateful.

Introduction

The present seminar is a brief overview of the theoretical studies, toward implementing the industrial bioproduction plant in Zakaria Pharmaceuticals Co. The whole executive results