Drug Response in the Elderly

The response to drug treatment seen in the elderly is very different to that seen with younger patients. Altered drug response in the elderly is often associated with changes in the body that result in modification to the pharmacokinetics of the drugs in older people. Absorption changes result from Morphological changes to the gastrointestinal mucosa. GI function changes have an effect on enzymatic breakdown, dissolution, and drug ionization which then leads to alterations in oral drug absorption. Intestinal absorption of some drugs is delayed due to reduction rate in gastric emptying. Another example is Elimination changes, which are caused by altered pharmacokinetics in renal function. Diminished renal and hepatic function can have a profound effect on the metabolic clearance and pharmacological effects of many drugs. This depends on the disease state, and drugs used. Reduced glomerular filtration rate, tubular secretion, and blood flow cause decreased elimination by the kidneys which in return increases the half-life of the drug. If dosage is not modified as needed, serious drug-related problems